AoE3 is OFF my list since its XP only. I'm not going to downgrade my OS to that.
I would like to see a real MOO4. NOT by Quicksilver. MOO3 was horrible! They glorified their 3D combat, had videos showing the art department working on the 3D models of the ships ..... and if you zoom in all the way, each ship is ONLY A FEW PIXELS BIG? MOO2 graphics, now 10 years dated, are BETTER! Not to mention the horrendous bugs, the drastic complication to micromanaging (you could do so much more micromanagement in MOO2 with a lot less frustration and in a lot less time!), etc.
Another take on Birth of the Federation would be nice .... the game very badly sucked but it did have promise. Supposedly its easier for game developers to use the full Trek license and not just be restricted, so imagine Birth of the Federation starting with the NX class and going through the Enterprise-J ... with a MUCH better game engine, of course.