1st City -
What luxuries do I have? Are they mining based or calendar based?
If mining based, I'll build a worker right after building a scout - If Calendar based, I may build a monument before I build the worker
The idea is to have a worker ready when I can hook up my first luxury...
Then if I have trees in my first ring, I'll cut them for the early hammer boost...
By then I should be able to hook up horses if I have any (which I never do LOL)
At this point I will either:
a. Ally a maritime CS
b. Hook up a food resource
c. Build a few farms
Then it's mines on hills, and trading posts anywhere there's a innate coin in the tile
2nd City and Beyond -
Hook up whatever I came here for (2nd city is usually settled near horses)
Hook up some food
If it's a good production city (hills and trees)... start ramping up hammers
If it's a good money city... TPs hard and fast
But then again... I'm not an elite player by any stretch.... so

consider carefully before taking my advice
EDIT: And Oh yeah.... TP every jungle then build a university - THAT's a nice tile