I'm not a great player by any means but I started a game last night to give this a shot. Big & Small, Epic Speed, Standard size, Noble difficulty.
I went with Suleiman of the Ottomans as my leader for imperialistic and philisophical. I figured that I wouldn't need to run the esp bar at anything above 70% to get good results so Imperialistic would let me ReX and the extra gold from not running a high research slider meant I could have more cities. I had good land, access to all early strategic resources, no happy ones though.
I grabbed Mining, Agri, Animal Husb, Writing, BW, IW, Alphabet in pretty much that order, writing might have been earlier. I spent my time making warriors to explore and fog bust as well as getting into position for the settlers I chopped out, coincidently my capital had 17 forests in its fat cross initially, those helped alot.
As per the challenge I dropped my research bar to zero once i finished Alphabet. I quickly had enough food online to run 2 scientists in all four cities. I quickly got 3 GS which I settled 2 in my capital and made an academy. a fourth one i used to lightbulb a tech, I belive it was Philosophy. In the mean time I was trading expensive techs to back fill.
Everything seemed fine til I noticed that I was on a continent with 5 other civs!!!!

Alexander DoW'ed and sent a few phalanx to bother me but he was far away, I didn't understand the DoW until 20 turns later when Caesar who was righ tnext door also DoW'ed and came a runnin' in.
I quit at this point chalking the game up to my lack of forsight. I had a small army but not what I normally would have and not enough to defend from two aggresive civs. I did learn a few things however.
1. My initial strategy worked, ReXing then fast tracking to libraries and using SE was easily equivilent to my normal tech speed. (i normally use CE)
2. Tech stealing isn't hard but I should have weighted more points against my neighbors and conentrated on them instead of spreading them out to civs that were to far away logitically for a spy to get to without getting caught.
3. Suleiman has potential. The Ottoman UB (Hamann??) replaces aqueduct and adds 2 happy on top of its normal 2 health. With all those specialists running I was popping GS like crazy, that could be addictive.
Thoughts or Comments? Especially on leader choice seeing as no one else has mentioned him yet in the thread.