Well I could live Without corruption/waste (or at least with it almost totally gone) but personally I think they should actually expand on stuff like rioting/pollution (possibility of new civ forming out of civil wars/different types of pollution, Chemical/air/radioactive)
I'm really hopeing that there is some kind of unit countering relationship, (pike beats horseman, archer beat infantry, etc) though it looked from the "developers rant" that they did not like the idea of that.
I have to say that I'm a little disappointed. They said they want to "simplify, simplify, simplify" the game, that tells me that there buying into the console-enduced "dumb" gamer, who can't handle complexity, games over 45 minutes, or anything that might actually require thought or serious effort.