Yes, Antwerp was a great and very rich city at the time, because of its large seaport that was very imortant. Later, when the Dutch revolutionists (geuzen) took control of Zeeland and blocked the Schelde (the river that is between Antwerp and the Northsea), no ship could reach Antwerp. The rich traders went away, mainly to Amsterdam, together with all the banks that couldn't make any profit when there were no traders. Also the Jewish and few Moslims flet away from the anish Nertherlands because of the Spanish that wanted to destroy all non-catholic population.
In my Dutch Modpack, there are just 4 changes in the city improvements, all wonders have been edited, the icons are new (except for the improvements that weren't changed), there are new units (mainly new ships, and a unit called poldership that can change water into land) and units are replaced (new unit is the UN Soldier coming with the advance of Communism, together with United Nations. It came for the partisan.) I'm working on a new advice.txt. Ofcourse the terrains are edited and I'm thinking of making the cities.gif a little bit different. There are a few new advances (shipbuilding, sailing, polders), and also a few new civs (Dutch, Belgian and I'm working on Surinamese and Indonesian because they are heavily related to Dutch history as colonies)
For the scenario, there comes a new units.gif, rules.txt in comparison to the Dutch Modpack.