Played it as Byzan, took out most of Arabia in the course of three wars before they cap'ed to me, I had left them most of Iran.
Sent Caravels to the new world and converted Monty to Christianity and gave him alot of techs for free for or for gold in order to butter him up and to help keep any europeans from colonizing too much. Now he will do what ever I want.
Abotu the time I got rifling I attacked India, which triggered a world war with most of the world against me. First India became a protectorate of Russia (who was my 2nd best friend in the game till this point), Mongolia and shortly afterwards China joined the fight. Then France and the Holy Roman Empire declared war. Through it all I took out most of India (they were spared with an out of way city), held off China's feeble attacks, conquered French West Africa (including Versillia) and a few worthless Holy Roman colonies in west Africa.
Just as the fighting was dieing down with me making peace with most of my enemies, Spain and their Mali vassel declared war. Excepted for their far away colonies in southern Africa, the only places I could fight Spain was by declaring war with other civs to pass throught their lands (which I did with the holy rome in order to send ships). Didn't want to attack Mali since I wanted to send my forces to this area in central (real) russia that Spain had managed to carve out a little empire by taking some barbarian cities. That and I wanted to focus on building up my cities some more after fighting a massive war with russia india and france. So my central asia Spanish invasion failed, thou I did raze one city. I did manage to get Monty to terrorize Spanish North America, and even amanaged to take a few of their cities, with 3/4 of north america being Aztec now.
I stopped playing since my computer was having a heart attack in the modern age. I was researching Fission and was also ready to work on Rockety. Wasn't sure if I wanted nukes myself or to get the non-prolife pact signed, but the French who were in charge of the UN didn't seem interested in a non-prolife pact.
I had controlled all of the Middle East, India, and Northwestern Africa and Western Africa. Iran was my Vassel.