Ok! I have had a quick look at your game. And I think I have some serious recommendations for you 
Improve more land! Build a lot more builders and use them. The land around Uruk is almost untouched. Remember, after you research Bronze Working, you may remove the jungle, and build a farm there for example. You need to do that in two different actions. (Buldozer icon). Additional bonus: Removing jungle (and forest) adds a one time boost of food and production to the city who owns the tile. So it speeds up the production and shortens the turns before city growth.
I think this is probably the major reason why winning is difficult in your games. Do not be afraid to remove forests and jungle. You need that space for farms and districts. You may later use some forests with a lumber mill, but you also need food for your people.
Other big tips from this savegame:
Buy buildings and units for cash. You have almost 6500 gold. You can buy a hell lot of builders for that. Depends on how you play, gold may or may not be a resource. But you should not leave it untouched as long as you have surplus cash.
Use the unique building. You are playing as the Sumerians. They have the unique Ziggurat. You should build that all over the place in the start. Especially around rivers. (But remember to build some mines for production). Later on you want to replace them with more powerful buildings like dams and such. But they are a key building for early tech boost. For example: Around Uuruk, you can use the builder to remove the jungle along the river and build Ziggurats there.
Do not forget to build the monument in new cities. This is of course situational, but in general the monument is one of the first buildings you should build. The monument speeds up the rate which the city expands, so you do not always need to purchase tiles for coins. It also speeds up your civic research.
Some minor improvement:
Change the government. You may want to spend some coins to change to Merchant Republic to get more trade routes and more peaceful policy cards. For example those that give you more science from trade routes.
You have a religion. Might be an idea to use it. Build a holy site in one of your cities with the religion and build a shrine and temple in it. Then buy an apostle with faith. Use it to evangelize faith. Then you can for example pick up "Wat" which enables you to build a Wat in cities with your religion which gives you +2 Science.
I think this is enough for you to work with in this game and in a new game. Start with exploring builders and what you can build with them.
Improve more land! Build a lot more builders and use them. The land around Uruk is almost untouched. Remember, after you research Bronze Working, you may remove the jungle, and build a farm there for example. You need to do that in two different actions. (Buldozer icon). Additional bonus: Removing jungle (and forest) adds a one time boost of food and production to the city who owns the tile. So it speeds up the production and shortens the turns before city growth.
I think this is probably the major reason why winning is difficult in your games. Do not be afraid to remove forests and jungle. You need that space for farms and districts. You may later use some forests with a lumber mill, but you also need food for your people.
Other big tips from this savegame:
Buy buildings and units for cash. You have almost 6500 gold. You can buy a hell lot of builders for that. Depends on how you play, gold may or may not be a resource. But you should not leave it untouched as long as you have surplus cash.
Use the unique building. You are playing as the Sumerians. They have the unique Ziggurat. You should build that all over the place in the start. Especially around rivers. (But remember to build some mines for production). Later on you want to replace them with more powerful buildings like dams and such. But they are a key building for early tech boost. For example: Around Uuruk, you can use the builder to remove the jungle along the river and build Ziggurats there.
Do not forget to build the monument in new cities. This is of course situational, but in general the monument is one of the first buildings you should build. The monument speeds up the rate which the city expands, so you do not always need to purchase tiles for coins. It also speeds up your civic research.
Some minor improvement:
Change the government. You may want to spend some coins to change to Merchant Republic to get more trade routes and more peaceful policy cards. For example those that give you more science from trade routes.
You have a religion. Might be an idea to use it. Build a holy site in one of your cities with the religion and build a shrine and temple in it. Then buy an apostle with faith. Use it to evangelize faith. Then you can for example pick up "Wat" which enables you to build a Wat in cities with your religion which gives you +2 Science.
I think this is enough for you to work with in this game and in a new game. Start with exploring builders and what you can build with them.
