Yes, but try the Rise of Rome Conquest playing Macedon. You're locked in eternal war with Persia (which has a huge territory, good resources, and is determined to fight you every step of the way.) In order to achieve ANY respite from this large struggle, you have to slog everything down to the defiant, far distant corner of the map, and exterminate every last remnant. I had defeated and contained them, but they would never listen to reason, never talk peace.
And as long as any Persians live, they keep instigating/bribing everyone from Egypt to the Huns to the Celts (!) to the Carthaginians (or even Rome, if i'm not diplomatic enough) to attack me. (It's a Conquest of shifting alliances, with more diplomacy than i expected; and a really fun epic struggle.)
Meanwhile, my other neighbor, Rome, has become my rival to winning the game...
Eternal war seems too extreme. Only a Hitler fights to the last basement.