I don't get into many nuclear wars, but I would imagine that it would annoy me greatly to have my nukes shot down.
A remedey to the overpowering ISD could be "Intercept Missiles" designed to intercept nukes. Kinda like a fighter where you station them in a city, and if a nuke targets it, the missile would intercept and negate the nuke. Not sure on the % of success, or cost of these missiles, it's just an idea.