Here are the setup/ rules I play by:
Difficulty: Apollo
Victory Conditions: Domination only
Map: Pangea
Affinity: Always go for Supremacy
Tech beeline (generally speaking): Pioneering, Physics, Chemistry, Engineering, Autonomous Systems, Robotics, Communications, Collaborative Thought, Euthenics
Wonders: I pick up all the associated wonders along that tech path
Virtues: under Prosperity beeline to Colony Initiative, then under Might beeline to Scavenging, then under Industry beeline to Standardized Architecture, then back to Might to beeline to Martial Meditations, then back to Industry for the economic benefits.
About the time I am researching Euthenics I am also close to getting the Adaptive Sciences virtue. Up until that time the AI is very ahead of me Affinity wise, which can make for some very pitched battles (especially if I am in the middle of the Pangea map). Good way to stay occupied during the winter months.....
D