Just for a bit of fun, I relocated the Aztecs (via world builder) from the mainland to a tiny island in the middle ocean, cut off from the rest of the civilizations. The island has a maximum room for 3 cities. The first picture shows the initial setup, and the second one is my progress in 1400s. My goal was to get off the island and contact other civs, so I pretty much beelined for optics, with exceptions of some useful worker techs and polytheism. Despite my small empire size, I was able to grab the great lighthouse and the colossus. Catherine came around in caravel in 1100s and discovered me. Not long afterward, I got my own caravels, and start sending out missionary to convert other civs. Anyway, you can download the attached save files, and try your hand at this challenging setup.