You'll want a pretty spread out layout. Depending on the terrain, I find CxxxC is best (where C = city, x = tile in between). It gives cities enough room to get around 75 spt, but also grow past size 12 to get increased unit support, bonus shield if industrious, etc. With this layout you can get a number of powerful cities, with little corruption and less waste.
Scientific civs always help, but if you aren't one, and early library in your capital can do a lot. Timing your golden age for the middle Middle Ages is also nice, especially if you are not scientific, to get your cities to size 12, and build those expensive Universities and Marketplaces so you will be producing the most commerce you can. I think ToE isn't a must, but it is very easy to obtain with a prebuild (ie; a palace in some other city, and then switch it to ToE). Have a similar prebuild (old wonder, expensive improvement) in place for Hoover's if you can, to save you tons of money on commerce.
If you have a smaller civ (ie; you haven't gone in a war / taken many cities), Democracy or Republic is good for the commerce bonus and low corruption. If you have a big civ (you wiped everyone out except for some cities / you have lots of corruption), Communism is good to get all the commerce out of those corrupt cities, but just make sure your core cities have courthouses / police stations so they don't get more corruption than they had.
The Internet is also a nice wonder, especially on a pangea. It'll fill the gap between newly conquered cities which have no culture, as well as speed up research by almost 25% at no cost to you, just prebuild in advance. Sell techs for gold per turn so you can keep your research up high.