Hey Duke, After reading the topic, I was about to make a post that it is possible to play an OCC game without wonders, except Apollo. If you play a standard OCC, a spaceship is required, so there is a no-wonders OCC... but the exception is that you are allowed to build the Apollo program, since that is required to lauch the space age.
Now what I have not seen (and not even considered actually attempting) is a Size 4 or a Size 1 "No Wonders" OCC <img src="icon12.gif" border="0"> . BTW, since OCC games are done at deity, an easier level can't be used as a crutch.
For Non-OCC games ("regular" games), it is much more difficult, but definitely playable, if you never build a wonder.
You might try the variation that forbids you to ever build
or control a wonder. That's a challenge, and takes planning if you play a normal 100-150 city expansion game. Growth is slower, and lots of resources are wasted that wonders can save. When you see the yearly bill for 200 cathedrals, it sure makes you appreciate MC!!