First time post but what the hey...
Just got into Civ4 a few weeks ago and figured I'd register here and give this a shot. Did some forum reading and played one or two quick games into the modern era with different settings to get a feel for it first.
Decided to be aggressive early and took out both Hatty and Hannibal by 1480 AD (ok, it wasn't a super rush

). I then settled in place and started building up and was being culturally squeezed by Brennus for a while. In retrospect I probably should have taken him out too.
I kept changing my mind on what victory I wanted to go for but after meeting Vicki I realized that she was ahead of me in tech and I wasn't going to catch up. She proceeded to beat me to a few wonders by less than 5 turns which was frustrating. After reassesing I realized that I had settled too long and was not confident in amphibious assaults so I decided space was going to be the way to go (I wasn't going to be able to reach the culture goals before spaceships despite leading the culture race).
I made a newbie mistake about 30 turns before my victory by accepting Brennus' offer to be my vassal and automatically declaring war on Rome who Brennus was DOW with. I ended up saving Brennus' bacon and managed to get some gold out of the deal when I convinced Augustus to cease fire (at that point I was in the midst of building my spaceship).
Ended up winning in 2019 AD. Definitely made some mistakes and picked up on some things to try next time. For my first Civ4 game actually completed though I was fairly happy.
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I did make one early decision that I am curious if someone can comment on though. In order to block Hatty early before I rushed her I settled my second city 2N of the rice. I'm not sure if this slowed me down a lot or if it was a decent idea. Something like this wouldn't work on a more Pangea like map but on the maze I thought it might be worth it.