It depends, I play on the most "realistic" map that is mysterious (Fractal in thsi case). I tend to use randomizer to pick the civs so I can actually name the leaders instead of having "PLayer 1 of the Shoshone".. I usually have this affinity to mirror the activites of the AI, so i settle more or less 3 tiles between two cities. It's less straightforward as it allows me to choose how each leader is played. For example Ramesses will research Wonders more than say Shaka, but Shaka will quickly start building an army, if there's a city 3 tiles close there might be a war.. it just relaxes me as I can anticipate and not get stressed over a sneak attack, but in theory, I can't lose, I do both, win and lose.