I, too, was concerned about the strategic resource issue prior to buying the game. Frankly, it has not been an issue for me. I have always had the resources that I needed within my territory; or at least close enough that a short war would net me the resource.
Frankly, it is the luxury resources that I find harder to acquire. They seem to clump on various parts of the map. This forces you to trade for them. You can also use temples, entertainers, or the luxury slider to compensate, in addition to your trading. Most importantly, though, your marketplaces will amplify the value of your existing luxuries. So, not having all 8 luxuries has not been a major issue either.
The acquisition of resources (strategic or luxury) is just another interesting aspect of the game. Disclaimer: my playing is still at the lower difficulty levels, having just recently started my first regent game.