Since I have read the threads relating to fighting corruption, playing at the standard level feels a little bit like cheating. The only way to remove the guilt is to increase corruption. Besides, soon Firaxis will cave in to pressure and give us artillary units with the ability to fight corruption.
In response to the "Settler Diarrhea" diarrhea that turns up in so many threads - take some first person shooter medicine and get over it. The European settlement of the new world comes to mind of an example of settler diarrhea run rampant. I concede it is not a perfect parallel to the game, but the urge to expand and settle has often caused tension, conflict, and warfare throughout the history of civilization. The American revolution can be seen as a model (though concedingly not perfectly parallel model) of corruption and city flipping. The colonies could never be as productive for the crown as English cities and the colonies flipped (though concedingly not to the native culture). England tried to take the colonies back through warfare, but failed to do so.
Corruption in modern day America? What percentage of Hawaii is owned by Asian interests and thus not fully benefitting the U.S.? Environmentalists have caused us not to make full use of the productive resources of Alaska (although why would anybody settle there anyway - too much tundra). You think South Central Los Angeles helps contribute fully to the productive capacity of Southern California? Texas and California politicians and corporations are responsible for rolling blackouts in California, thus causing corruption and waste. A little of an off topic rant, but CivFanatics has the Zouave Wonder which increases science through making valid points about shortcomings of the game but causes unhappiness through repetition.