The bug is about the graphics for the Spanish Great General in the Renascence age (or the age that starts with Astronomy). That is why it happens in the late game.
Do the following, start a game with Spain and enter the WB. Add one great general for Isabella and then start adding techs. Once you hit Astronomy, the game crashes. This is the same crash as reported on this and other threads.
Agree. I had a crashes too, in 315 turn. There was no way. Killing the spanish in WB was the solve of problem.

Interesting start: Spain was well above everybody with a score over 2000 points, had Napoli and southern France. Germany expanded into Austria, Hungary and Poland and also vassalized Poland. Denmark and Groningen were English. Some city in Bretagne declared independence, I think it was an English city, France only has one city left, probably Nantes. Turkey isn't doing much, Venice has the entire Adriatic, Firenze and Constantinople. Sweden expands nicely into Finland. Others are doing pretty regular if still alive.