Well, this is what I do on turn 1:
a. set research to universal translator or its pre-req
b. design custom colony ship with max number of engines with at most 1 life support
c. buy factory, buy custom ship, start building another factory
d. set tax rate to whatever rate that maintains >70% approval, set spending to 100%, set military rate so chat you'll be producing exactly 1 military shield, put the rest in social for that second factory
e. if you had a 300% or higher production bonus square on your starting planet you might have some $$ availble for research
f. land the starting colony ship you have an relaunch with whatever amount of troops you want (this does nto waste movement points)
g. send colony ship out one way, send flagship out the other
On turn 2, I might buy another colony ship and whatnot. Anyway, the general strategy is to leverage the 5000bc as far as you can. Do not research beyond universal translator (except maybe propulsion stuff if you can afford to tech to impulse cheaply). Do not build any research or influence related buildings. Your build order on your main base should both be very much alike:
factory, factory, morale, econ, econ, econ, econ, ......
There should be no specialization, no research, and no money spent for any purpose other than the main objective: to increase your per turn income. You can specialize and research later, but not now. Trade techs profusely, but never under any circumstance trade away universal translators. Try not to acquire techs that give you improvements that you'll rather not build or rush in the beginning. Try to make make every colony (except the capital) have an coordinated number of factories. Every colony should either have 2x factory capability or 4x (or 8x if you happen to find a precursor mine). That way you can synchronize your production levels to produce exactly one trade center every turn or one trade center every two turns with no waste. If done well, your income per turn should overtake your expensese per turn before your treasury runs dry.
I play at 3 levels above normal on large with everything else normal and 9 opponents. I usually play Yor.