So as to close the year with a positive note 
I think that for my own generation and around it the most prominent one was the Cobra Commander.
But my favorites were from the bleaker/ more monstrous animations, such as:
Monstar (archenemy from Silverhawks)
Really...![Pimp [pimp] [pimp]](/images/smilies/pimp.gif)
Inhumanoids had the overall best plot/monsters/atmosphere, but the actual enemies were not as cool. Apart from a non-regular Inhumanoid, Sliver:
Yes, i still recall the first scene he appeared in, being woken up in some jungle temple, by a flute player...
Link to video.

I think that for my own generation and around it the most prominent one was the Cobra Commander.

But my favorites were from the bleaker/ more monstrous animations, such as:
Monstar (archenemy from Silverhawks)

Really...
![Pimp [pimp] [pimp]](/images/smilies/pimp.gif)
Inhumanoids had the overall best plot/monsters/atmosphere, but the actual enemies were not as cool. Apart from a non-regular Inhumanoid, Sliver:

Yes, i still recall the first scene he appeared in, being woken up in some jungle temple, by a flute player...

Link to video.