Its rare worth to have city producing 80-90 shields, than two producing 50-60 shields. Pop of these both two cities, added is more than one single city. U will have two universities, two libraries, two banks, two marketplaces, almost doubling output from these two cities( minus buildings support of course). I use C**C placement, depending on land, but in this case, my core consists on lets say 15 cities able to produce tank and infantry for two turns, which is far than enough for huge wars, two. Add also 20 cities able to produce them in 3 turns. My cities usually grow to size 14-15 max, thus giving me metropolis unit support and giving me options to add some policeman to round the shield needed for particular unit production. I never calculated them exactly, how better it is, but overall look tells me its lot better to have core of relatively small metropolises, but many of them, than only few really large metropolises. Ah, also, its good to have one well developed, really large city, for wonder building, although, when wonders are available, u cant reach pop over 12. For such city its good to hit Shakespeare theathre, so it will become descent before availability of hospitals. Also - the more cities - the more units support. Usually u wont get all land u see on EMperor and above levels, so get it used in best way, meaning all tiles worked at earlier stage