Have an idea for some of the more popular wonders and buildings. Instead of unlocking them once a certain tech is researched, have them unlock once you reach a certain age. Say the Great Library opens once you reach Classical and Notre Dame once you reach Medievil. That way you can go along the tech route you want without having to go the same route for the first part of the game. You could follow the bottom of the tech tree if you are going for dom victory or middle if you are going for diplo. Have one or two of the oft overused wonders that open at a certain age. You can still have the rest of the wonders that are more directed toward the victory condition you are going for open at certain techs.