I play on Noble (no advantage to either side) with Elizabeth on large pangea maps.
If I just want to win the game easily, I chop rush cities to sane places, try to expand at the correct rate, found religions, make friends, try not to get rolled militarily, and either do space race or kill everyone with tanks.
Cultural victory is harder. The times I've done it, I've planned for it. I've made three or four cities that are heavily cottaged and probably inland. I've religion-hogged. I try to get 9 cities and 3-4 religions.
It's tricky to get temples everywhere, and cathedrals in the right places, but if you can do this while avoid getting militarily crushed, and have democracy and rifling ready to go by about 1600, you can turn culture to full blast, rush-build any remaining religious buildings, put military units on your borders, and win pretty easily sometime around 1900. Your score probably won't be very high.
The last time I did this, I wasn't paying attention and ended up with four or five too many great artists. I also don't micro-manage specialists that much.
This is trickier than playing a "normal" game, but it is certainly not impossible.
It is not necessary to go crazy with wonders, although on this difficulty you'll get a lot. With a nice cottaged city and a bunch of cathedrals you can get maybe 600-900 culture per turn in a good city.
bruce