Honestly I'm not sure it maps well enough to make a coherent mod. Minecraft has almost no context so at the 4X scales there's really nothing unique to draw from it, except maybe a few units. I mean you could try to replicate the biomes as terrain, crafting recipes as resources, gear specs as units, etc, but I don't see it being more than a gimmick. A Minecraft terrain/UI pack could be fun though.
Kind of a shameless plug here, but if you're interested in going in the opposite direction there are some civilization-themed Minecraft experiences out there. Specifically the server "Civcraft: Build with more than just blocks", which I've been linking in my sig for a while. It's a social experiment focused on competing political and economic ideologies in a sandbox world. Several empowering plugins and a hands-off administration put the onus on the players to forge their own societies from scratch. Note this is not the same as the CivilizationCraft mod/server inspired by the Civ series nor the CFC server run by Croxis; I have not played either of those so I can't comment on them but they do seem to be explicitly "big-C" Civ oriented while Civcraft is more about recreating the concept of a civilization.