Just finished my first Post-Release Game, and there were a couple of new experiences in it for me, even after 420+ hours playing the test versions.
First, game ended at Turn 260 when I finished researching every Tech in the game - first time I've ever done that in a game, although many other testers did. By that turn I had also maxed out 4 of the 7 Era Stars and had all of 5 Stars left to have won Twice by getting all the possible stars in the last Era. Never even came close to that before.
Finally, and most interesting to me after having earlier pre-release test gams drowned in Pollution, I found that Pollution was, in fact, manageable if you pay attention. It helped that all that Science put me in the Technological Lead so that I was also the major Polluter in the world, but by planting new Forests (which is dirt cheap, so it doesn't even slow up regular production much) and building/buying Renewable Energy Infrastructures as soon as they became available technologically (Solar Farms, Wind Farms), I reduced Pollution/turn from over 400 to 45! And this despite having built Train Stations in every city and most attached regions (I loe watching the little trains chugging back and forth between my cities) and lots and lots of Polluting Infrastructures (Coal Plants, etc). The kicker was when I beelined to Fusion Reactor, one of the "Future" Techs, which gives -50% Pollution on all Territories - dropped my final Pollution to 17 per turn.
That was gratifying, because it means I can keep playing the game without having to cut off my games in the late Industrial Age because I can't stand how Pollution makes the map look - grayed out and ugly.
Pollution still needs some more balancing/tweaking, because Global effects kick in too early while Local effects, if anything, kick in a little late: the term "dark Satanic mills" to describe the coal-smoke-polluted air around the early steam-powered factories dates from the beginning of the 19th century, after all, and massive deforestation and pollution from charcoal burning dates back to the Early Modern Age (Renaissance).