I'm all over this like gangbusters. I've been playing Civ since Civ 2 came out about 13 years ago. I've played all four of them as well as Smac/Smax, but have only been playing Beyond the Sword for a few weeks, and I've never had any kind of multi-player experience beyond occasional Hotseat games with my wife, which we usually abandon after a while, so I'm really looking forward to testing my chops against actual human players.
As for the settings, I usually like to play with the biggest map available, with a few continents, but Pangaea is okay if you want. Free-For-All is good as well, and personally, I don't think we'll need any more AI's depending on how many more people get in on this game, but if a few make it, it's all good by me. Should we do leader/civ mix-and-match? And if so, who does everyone want?