No.
I want to be able to lose to an opponent because my mistakes were punished by better play, not by a handicap.
I used to play a lot of chess - and it was far more fun to lose to a better player than it was to handicap my queen away and still win against a newbie. I'd also get better faster that way.
Some implementation of handicaps is OK: for example, I don't mind the ones that encourage smart strategic play by the AI by way of making it a little easier, such as cheaper unit upgrades leading to saving highly promoted units.
But other handicaps turn into a crutch, and that sucks. An AI with a bonus to building wonders, plenty of mines, and a relevant resource shouldn't *need* a decreased cost in order to beat other civs at finishing that wonder.
The fact that Deity civs start with a free settler actually *could* make for an interesting tactical scenario (kind of like handicapping your queen in chess) without any further bonuses relative to Immortal - but that would be require an AI with the ability to leverage how absurdly strong starting with two cities is.