Additionally, make sure Civ 5 bad habits don't carry over.
DON'T:
-Found 4 cities, sit on them all game, and expect to turtle win
-Spam archery units because ranged attacks are OP (there are no more ranged attacks in IV lol)
-Build 4-5 archers and think that's sufficient defense
-Put a farm on every tile
-Neglect commerce, because arguably the most useless resource in V can now be put in just about anything and is by far the most important
-Be afraid to use slavery
DO:
-Axe rush if you have copper, high production, and a non-protective neighbor too busy building Stonehenge
-Settle near gems/gold/silver, the early extra commerce is insane
-Get currency, code of laws, and civil service ASAP for markets, courthouses, nonriver farms/bureaucracy
-Beeline liberalism for free tech, though don't rush it too much
-Remember that militaries should be 5-10 times LARGER than in V to be adequate, because lowered production costs and more cities mean if you don't, Shaka will come and take your stuff
-Remember that resources are MUCH more powerful than in V (especially early game wet corn, 6f 1c)
-Remember cultural victory is very different
-Remember science victory takes far longer and needs ~15 parts built with spaceship travel time as well
-Remember to connect your cities and resources