K first I assume you are getting the most recent patch from
http://hometown.aol.com/cedricgreene/ . Either you can download the four .ace files, "MGEPatch.ace, MGEPatch2.ace, MGEPatch3.ace, and either MGE-242.ace (for classic Civ 2) or ToTtoMGE.ace (for Civ 2 ToT)" or you can download MGE-242.exe or the ToTtoMGE.exe for the appropriate version.
If you download the .ace files you will need a copy of WinAce 2..00 or later which you can get from
www.winace.com to unzip them. These files need to be extracted to the Civ 2 folder eg. C:\mps\Civ2\ or C:\program files\Test of Time\ , if/when it asks you to overwrite current files click yes/ok. After that is complete then go to
www.ligos.com and download the latest Indeo video drivers and codecs. Make sure your Civ 2 disc is in the drive and start up the game.
If you download the .exe please make sure you have recently installed a copy of Civ 2 and have not modified it in any way (except using the official patches to upgrade it to the latest version 2.42 for Classic and 1.1 for ToT, which is necessary), double-click the .exe and put in the directory which Civ 2 resides eg. C:\mps\Civ2\ or C:\program files\Test of Time\ , the .exe will take out the unnecessary files and add the necessary ones. Go to
www.ligos.com and download the latest Indeo video drivers and codecs. Make sure your Civ 2 disc is in the drive and start up the game.
This should get the game up and working, if for some reason it didn't work uninstall and reinstall the entire game then the official update and finally my patch again strictly following the instructions. IMPORTANT!!! This is only for the PC versions of Civ 2 that have been installed in English, and possibly won't work with other languages, though I have been told it has worked with Polish, Russian, German, French, and Spanish versions.
For scenarios you need to have a scenario subfolder Civ2\scenarios\ which you will create a new subfolder for each seperate scenario inside of the scenario folder eg Civ2\scenarios\War1812\ or Civ2\scenarios\CivI . Almost all scenarios work with MGE so they should load properly if setup correctly.