I spent the first five games missing Liberalism and/or getting beaten up by our friendly neighborhood SOB. In the first three or four games I tried to REX to six cities, but gave up and decided three would be better. I eventually built two more to grab health resources, then one more for Oxford, but by then I had to start on the Manhattan Project instead of NYU (New York University).
It was pretty sweet that New York built both the Manhattan Project and Broadway, as well as being the Jewish holy city.

Didn't have time for Wall Street, though.
Washington was commerce, New York was hammers, and Boston was food. All your food groups. I thought I'd adopt Caste System, but by the time it would have made a difference, Great People weren't paying off as much any more, so I never did.
Started with HR/Bureau/Serfdom/Merc/Pacifism. Adopted Judaism ASAP and switched to Free Religion ASAP. Eventually switched to Representation on a demand from Napoleon.
First builds were micromanaged to get to Liberalism.
Washington: Library/Barracks/Longbow/Longbow/... I had to focus Washington on growing pop so that it could work max cottages. Eventually it built Aqueduct etc.
Washington ran 2 scientists ASAP, then turned down to 1 after the first Scientist finished Education.
New York: Library/Settler/Worker/Worker/Barracks/Longbow/Longbow/...
Starting with Libraries was for the Mercantilism scientist. I tried Forge first in New York, but I think Library is better for more science.
Boston started Library/National Epic.
I think one could get to Liberalism a little faster by starting with more cottages rather than such extreme specialization. Similarly I don't think Boston needed max farms -- just enough to run 2 scientists, an engineer, and maybe a merchant would have sufficed. More cottages in Boston would have been better.
I'm not sure if it would have been better to skip the seafood-grabbing cities. I definitely didn't need Chicago. Maybe if I had been more careful about the whole thing I could have gotten Oxford, but it took the satellite cities a while to build their Universities.
Generally everybody stayed happy once I started tech trading, because I had a comfortable tech lead and traded on good terms. At first I was pretty aggressive about building units, then after the first few Grenadiers I slacked off. I was first to Chemistry by far. I didn't OB or trade resources much.
first scientist finishes Education
second scientist Academy in Washington
1280 Liberalism
third scientist speeds up Printing Press
1505 trade PP for Gunpowder and Economics
1605 Physics (first) scientist settled in Washington
1665 Chemistry for Nationalism and Replacable Parts
settle cheese city #6 and use GA for great work
1740 trade Sci Method for Constitution, Rifling, and 700
1745 give in to Representation demand from our pal
1750 Fission
1760 New York finishes Broadway, starts Manhattan Project (how fitting!)
trade spare Musicals for Dye, Wine, and about 20 GPT. Back to all happy in Representation.
Research Steel (can't trade for it).
Sci Method for Corporation
Physics for Military Tradition
OB with Julius; had it with Napoleon for a while. We're the Representation gang.
Saladin's pleased but doesn't really border.
GS Settled
1780 Steel
Physics for Steam Power
1806 Artillery
1818 Electricty for Railroad
1822 Rocketry
GS, Settled
1828 Manhattan Project
Electricity for Combustion
1844 Fascism. Revolt to Police State for pizzaz.
1850: THE BIG PAYBACK! Revenge! I need some GIT BACK!