Yeah...I do it all the time.
Especially Monarch. It's even possible without using a utility like CivAssist or CrpSuite, but I recommend one. Once you get to Demigod, you want to spend a bit more time with your games, whether it be in negotiations of trade, the early stages of your game (I got a settler factory up and running before 1000 BC. That really helped me grab some land), or war.
