As someone with a fairly shelf-busting collection of designer board games, I feel compelled to point out that Monopoly is the game above all others (save, perhaps, Candyland) that have informed modern designers how "not* to design a board game that people will never get bored of.The Runaway Lead isn't just a problem in the Civilization series (and other similar games), it's also a pretty common issue in board games. Take Monopoly for example. If you manage to make another player Bankrupt (**Lose**), you get their belongings. This gives you twice as many properties to work with, increasing the odds of you winning mathematically. Unlike Civ, Monopoly is a chance based game, but it is a game of probabilities none the less.

It is the norm to resort to what has come to be called "point salad", for exactly the reasons I specified previously: it gives players the ability to pivot rather than pursue rigid, linear strategies, often in vain.
It absolutely matters how you reach the end--or rather, how you are able to reach the end.Runaway Lead games generally have one major point to them, you race to the end. It doesn't matter how or when you reach that end, and if you snowball hard enough you can reach the end long before other victory options become available or whenever super-builds start to spring up (like canals, railroads, or maybe even super wonders lol). An example of this is in a game I'm currently playing of Civ 6. I'm playing Norway on Marathon speed on a Huge map, with lots of mods lol. I'm not even 300 turns in and I'm sure I could probably take out the other 8 civs by the start of the Industrial Era. Mind you, I've just reached Mideival, so I've got plenty of time before that. Hell, at that point, a potential World Congress won't change anything.
Sure, luck-of-the-draw can provide an advantage, as can poor decisions on the part of other players. The latter is something that has to be accepted on a game-by-game basis. The former is something we have to keep hoping to see improved by the designers. Ramp up the difficulty if need be. But all that doesn't mean there aren't other considerations for breaking up the monotony of a very predictable and by-the-numbers journey to victory.