I set up Europeans with exactly 2 cities each. If I start off Spain in southern Texas, this means they only get the one San Agustin city in Florida. This can be tricky both militarily and economically. It does actually work out well for France mostly because of their special honeymoon-like relationship with the natives (heck, France actually goes native by adopting the Cult of the Great Manitou over Catholicism fairly early...). Spain, on the other hand, is almost universally hated among nativedom. This could be bad.
The other issue is that by the 1640's, RW New Spain really hadn't established meaningful settlements in Texas yet. The only one to which I could find references is San Antonio, and it dates back to the early 1700's iirc.
England being split between Boston and Jamestown doesn't fare quite as well as France unless run by a player (which almost always leads to England getting both Catawba and Wateree, and going after New Netherlands).
Netherlands is nicely compact, but it is locked in with the Iroquois and Eries, so unless it gets really aggressive, it won't do much. Again a player can accomplish much with the Dutch.
I need to set up Abenaki as a foe for both England and Netherlands to motivate them to go after someone other than each other! Besides, the Abenaki are having it way too easy so far in the scenario. Then again, they might turn around and become vassals of the French.