I always disable Ancient Ruins and the Time Victory, sometimes shutting off the Diplo victory as well. On occasion, I'll turn on Allow Social Policy Saving, and I'll enable Quick Combat towards the end of the game to reduce lag.
Otherwise, I usually play with the default resource settings, though I do almost always add in extra Civs and drop back the number of City-States on the map.
Otherwise, I usually play with the default resource settings, though I do almost always add in extra Civs and drop back the number of City-States on the map.