Sure but thats a what if. I read a highly enjoyable SF novel by Robert Silverberg called 'Gate of Many Worlds'. Due to the effects of the Black Death the Ottomans conquered Western Europe, no Age of Exploration took place and eventually the Incas and Aztecs became great powers. Maybe it could've happened but it didn't. I wouldn't call the eastern end of Eurasia 1 huge landmass all to themselves. China shared the region with lots of other cultures but became the dominant one, something no single western culture (even the Romans) ever managed to the same extent.