Personally, I am of two minds about Humankind.
On the one hand, the map looks so pretty and considering I loved the 'feel' of the map in Endless Legend, I am sure I will love it here as well. I am also looking forward to seeing Amplitude's take on systems like tourism, culture, trade and religion.
On the other hand, some of the mechanics feel a bit... off to me. The Fame Victory condition seems to be a slightly modified score victory and while I appreciate they are trying to make sure everything your civ does counts towards the victory, and there is room for diversification if needed, I am still worried it may turn into a scenario where one player is ahead of all the others by a significant margin and you are just clicking end turn for 50 turns waiting for the turns to run out. There does not appear to be a mechanic to end the game other than waiting for the turns to run out, or presumably, eliminating everyone else.
I am also concerned with how picking civs seems to work- from what I understand you just get to pick from the ten at the beginning of an era, and I feel this may lead to weird combinations like Rome turning into the Aztecs or something like that. While cultures did change over history, and that is something Civ should try to model, they did not magically turn into another one from the opposite side of the globe. I think I would have preferred a system where you gained traits at the beginning of each era that were inspired by civilizations rather than becoming the civilization itself. From what I have heard on the Amplitude discord, you will also be able to produce ancient era units in the modern era with upgraded equipment and I don't like this at all.
I am very wary about the combat system. I have played Endless Legend a fair bit, and I found the combat system to be fairly horrible in that game so I hope they have brought big changes to it to make it more fun.
At the moment, I don't really get the hype for it myself, but I am looking forward to find out more.