Perhaps this will help. I have had all types of problems.
I could do the setup for the game, selecting the civ and terrain, but when I started the game it would frequently drop to the decktop, or end in a blue screen. Sometimes I could play a dozen turn or so and then get a blue screen.
I tried everything repeatedly. Deleting and reloading the game. Updating sound and video drivers. I even formated my HD several times.
I no longer have these problems. What I was failing to do was delete my old Nvidia drivers before updating. Even in the format failed because I was usinfg an older driver then updating it. It seems that us Nvidia users have been spoiled. The old drivers would install over the others without complaint.
The key step is going to the "add/delete programs" in "control panel" located in "my computer". Find the Nvidia display drivers highlight and delete. Then install the new drivers. Worked for me.