The only ship that's a problem is that dread. The other designs could be killed by IC fighters if they didn't have to worry about that energy pulsar.
The advantage to the Huge design is you could probably build 2 of the bomber design and one of the beam design as a decoy to their fleet, and that's all you'd need (though I really dislike building huge beam ships in most cases), as the humans couldn't overcome the autorepair, so you could safely ignore their fleet.
I won't say no to small missile boats of H-X or better very often, though, so I'm fine with that as long as we make sure to make enough of them. Those have the advantage of being reusable and useful vs lots of things.
My general inclination for fleet building is to build small missile boats, small bombers, and fighters whenever possible, and use the missile boats to take out things like that dread, then let the other ships clean up. I know that would work, and the fleet would be reusable, but, it'd take more time to build a fleet to deal with their fleet than a dread fleet that can ignore their fleet.
EDIT: Also of note if we're thinking of going for the Meklar next (man the Silicoids look a LOT easier)... the Meklar now have SCATTER PACKS.
We'd need to make sure we have a stack of bombers large enough to kill their bases in one shot or at worst two (with attrition) as those things will smoke smalls. I'm starting to think auto repair dreads with shield 5 might be the way to go, even though that goes against what I'd usually do.