I'm not going to spend too much time thinking about that, because I don't get a check from Firaxis to do so. However, Plague ( disease in general ) has really acted like an ' invisible civ ' in the real world and perhaps could act that way in the game. It could be sort of a ' pressure ' like the culture pressure - but it'd react and move differently ( and kill down your populations ) Sanitation and Hospitals help get it under your control ( giving the Scientific civs a little advantage ) Contact with other civs and integrating forgien workers into your populations should bolster your resistance. ( Integrating workers from other civs into your cities has to be good for SOMETHING right ? ) Isolating yourself keeps you out of wars but leaves you naive to disease - hmm - maybe you should buy those workers from the other civ and intergrate them into your cities ? In any case, Civ IV has GOT to model disease somehow.
Top three things for work in Civ IV : ?
Map
Disease \ Plague
Intelligence \ Espionage
Top three things for work in Civ IV : ?
Map
Disease \ Plague
Intelligence \ Espionage