I'm finally getting around to this scenario. It's great so far - I'm only up to Jan. 1516 and playing as the French. After one false start, I devised a new strategy. Instead of attacking Milan, which was my first instinct, I withdrew into Genoa and let the Papal army come to me. After destroying it piecemeal, I moved on Milan and captured it after the 10 turn war period with the independents expired. Thus I was able to make peace and avoided the English counter-attack. So far, so good.
I'm certainly enjoying it. The graphics are excellent, as in all your scenarios. It could sure use a Readme though. If you'd like me to edit the English grammar, I'd be happy to do so.