I'll place cities in bad locations just because they have outside the box strategic importance, like panama canal type stuff.
This last game I started as the dutch with a coastal start, it was in the shape of a crescent, there was a river mouth three or four tiles to my east connected to the coast so I put a city right at the head of the river even tho it overlapped my capital pretty bad just to get a near unbreakable trade route going, the river then went east for a couple miles, I rexed and put down a city along the river all the way down keeping them connected to the capital/sea by that first river city then the river started going north and a second river cut east some more going south/east and connected to the coast, so I put another city along the northern end of the river and one right inbetween the two to connecting the first river with the second one and then another city at the end of the second river at the coast where it connected to the sea..
They were alright cities mostly jungle nice grassland underneath with some resources you'd expect to find in the jungle, it prob would of worked too and given me a wicked foundation to build an empire off of but because I rex'd so bad and I was playing aggressive AI I lost one of the cities and just got upset and quit like a lil girl
I'm also a perfectionist, but I hate micromanaging heh
Also if I play the earth map I *have* to replay history, I'll try and get all the greek wonders in athens or I'll expand just like mongols did and raze demand everything, just a lil roleplay I guess, and if I'm egypt and don't get the pyramids I'll start over lol

nothing pisses me off like playing an earth scenario and not getting the pyramids when I'm egypt.
I usually try and play like the leaders personality in general, I guess that is kinda odd, it's fun tho. Specially when your playing Genghis Khan, I'll have -10 on every civ lol, I just go around demanding anything I want and if they say no I attack them and wont stop till I get gold every turn as tribute and when it ends I demand it again

and if they say no we go back to square one.