My current inclination is to keep Barbarians, Dramatic Ages, and Corporations on by default. Then, if I want fantastical elements (probably about half the time), add in Secret Societies, Heroes, and Apocalypse. I'm not sure about Tech Shuffle yet, but I think I'll tend to keep that as a separate sometimes-on option (usually in combination with the Real Eurekas mod). Zombies are the one mode I think I'll keep off pretty much permanently. They just seem too different in tone/genre than the "historical fantasy" of heroes, soothsayers and secret societies.