Don't we have enough dubious wonders?
I'd call the film industry more of a monstrosity than a wonder these days.
Bad culture is culture nonetheless. I wouldn't be surprised if certain wonders weren't designated as eyesores in their day. "A giant bronze statue over the harbor? Overcompensating much? Tsk, that's money that could be spent on more social programs!"
Modern wonders are obviously more subjective, since we can take feats of engineering for granted and recreate most wonders that ever existed, and probably in a much shorter time than they were originally constructed. The wonders of antiquity skate by on their place in history when any mammoth labor stood out.
As far as designating a site as a wonder, a la Broadway (or Disneyland or The Vegas Strip, etc.), we have stuff like Chichen Itza, Machu Picchu, and Angkor Wat designated as wonders that opens the door. I wouldn't say the Hollywood sign should be a wonder, but Hollywood itself could be. Then again, I would not disagree with someone who pointed out that America's film studio covers that unique and notable element of world history.
Personally, I think the most compelling cases for wonders now are based on Civ's mechanisms. For instance, a Vegas Strip wonder is compelling to me because it provides an argument for a late-game desert city, and could justifiably provide a significant surge in tourism for a culture victory (one that doesn't involve slots for great works of art). Plus, y'know....big neon cowboy.