The original post is a good rundown of the differences between IV and V.
Here's my take:
Absurdly Lacking MP Support - I never played MP, so this doesn't matter to me. Civ is just about the only game I enjoy more playing against the AI.
No SP Scenario - I never play scenarios either.
No Tile Animation - Does not matter to me at all.
No Religions - I kinda liked religion and wish it was changed instead of removed.
No Espionage - I always turned Espionage off in my games, never enjoyed it.
No Civics - Agree that Civics gave more tactical flexibility than Social Policies. I'd like to have both actually, I think it could work.
No Hamlets - Agree static trading posts are inferior to growing cottage/hamlet/village/town. Not a biggie to me, though.
No World Wonder Movies - Desn't matter one bit to me, never watched them anyway.
No End Game Cinematics - Dito.
No Commerce, Research and Culture Sliders - I actually like how the game is now more focused on population growth than just gold, gold, gold. Before, gold/commerce could be converted into anything: Research, culture, happiness. Now you have to have multiple focuses. I'm still undecided, but I am leaning towards accepting the Civ V economic system as an improvement on the old "sliders" system from previous Civ games.
No Random Events - Those random events provided no strategy, they were just, well, random.
User Interface - I also kinda preffered the Civ IV UI, but I think it's also a matter of just getting used to it.
City States - I like these so far, much better than Barbarian cities, for me this is a big improvement from Civ IV. Maybe could use some tweaking to make them less easy to conquer, though.
Framerate Problems - I am running the game on high settings and my computer barely surpasses the minimum specs, I am surprised it runs so well.
No Leader Personality Traits - We've got civ-specific "traits" instead. Personally, I would have liked both.
One Leader Per Nation - Doesn't matter much to me for the moment, will surely be modded in later.
Hexagonal Tiles - Awesome!
No Military Unit Stacking - I am very exited by this, I never liked the old combat system, Civ V is miles ahead in this aspect.
Strategic Resource - Another great improvement, I am loving this.
Fully 3D Leaders with Spoken Native Language - Pretty nice, but not important to me.
Overall: Civ V isn't exactly how I would have done it myself, but for me it's overall a clear improvement on Civ IV, and I am sure expansion packs and mods will make it even better - perhaps by re-introducing Religion, Civics, Cottages, multiple leaders and leader traits. Then it would be perfect.