Alright, let's do this thing.
1030 AD: The world is ripe for taking. Let's do it now. Start Chichen Itza to get some extra points. Karakorum is running scientists.

Remove them there and elsewhere. Micromanage all our angry citizens to starve and shave off a few turns on Forbidden Palace and other stuff.
There are a bunch of barbs pillaging around and are troops are galloping on goto orders towards Greece. Pasaragadae is defended by a single warrior and has a barb swordsman next to it. Priorities, people, priorities. I organize some homeland defense. 5th Immortals of Persepolis win against a barb sword on 23% odds. I have to whip a crossbowman in Memphis because it has a barb axe and archer in the fat cross.
Maceman loses to barb sword at 87.5% odds.

Forget about killing Alexander, we're going to be conquered by barbarians if we defend like this.
1070 AD: Alexander completes Great Lighthouse.
1110 AD: Chichen Itza completes. Good thing too, I was worried we were going to be run over by barbs.
1130 AD: I have enough of a SoD to take Athens. Declare on Alexander.
1150 AD: A CR III mace raizes Olmec in the mountains south of Greece.
1160 AD: Forbidden Palace completes. Alexander has crossbowmen and my macemen can't take Sparta now. I suicide a couple of catapults on Athens and take it with the CR maces. Must remember to send a thank you note to Alex for the Pyramids. I adopt Police State. Athens also has The Great Wall, so nyah to the barbs.
1170 AD: Harappan has longbowmen. OK, this could get annyoing yet.
1180 AD: Timur dies to a Greek crossbowman. Farewell, noble warrior.
1120 AD: I suicide a couple of catapults on Corinth.
1130 AD: Corinth is razed.
1270 AD: Argos falls and we have the most useless Great Lighthouse ever. Alex has three cities left, I have no idea where Knossos is. Tipu Sultan builds the Kong Miao.
1300 AD: Find Knossos. This was Spartaaaaaa!
1310 AD: Leonidas is holding up the fort in Knossos.
1330 AD: Immortals rush Leonidas' army and raze Knossos. One city left.
1350 AD: The longbowmen in Harappas sally forth to die in the hands of my Immortal scouting outside the sieged city. Well that should make things a bit easier.
1380 AD: Harappan and the Greek Civilization are no more. Persia wins a conquest victory.
It took 250 years to kill Alexander??? Cyrus seems to have dozed off while waiting for it to end. Good work everyone. Save included for posterity.