No, not really. That's why I try to play on Immortal+, helps keep you in check.
Although I did manage to somewhat run away on that level once.
Any game on Emperor or below becomes a runaway situation for me, especially as a science civ.
I aim to runaway with whichever victory type I'm going for. I don't like unfinished games and I don't like to scrape through. I hate that I always end up resorting to nukes though.
I wish I could but it gets tedious. This is perhaps the one primary reason I continue to wish for random events to help with the end game boredom. Quests add the personality of a civ and grant the player more of a chance to role play.
I do get the rare game in which I continue to play even after victory however. Because you want to see the civilization through to more greatness or a coming great battle....of course this is marred by the removal of other victories once a victory is already had. Which is sad. You can't, for example, launch the rocketship, once a cultural victory is had or have UN vote etc.
I really wish the modern to future tech tree was expanded and enhanced. Yes this means longer games....with the ultimate goal being a game which can turn on a dime several times during advancment through the history of a civ.