South America is interesting at first (usually tons of dye resources), until you realize that it's basically going to be lots of slogging through jungle and playing whack-a-barb until Astronomy...
I used to think the Amazon was the kiss of death, until I tried playing an Amazon specific strategy (Emperor, Vanilla)
1) Found on hills exclusively (else you can build nothing)
2) Beeline Universities
3) Spam cities
4) Trade post the jungle
an unintended consequence of the amazon university strategy is you end up rolling in gold and do not need it for a military.
5) Buy production buildings (and buildings in general)
6) Ally all your city states
7) Connect capital with harbors (not roads)
8) Liberty Policy tree
9) Commerce +3 port city production policy
10) Freedom Specialist policies
11) Rationalism Policy Tree
colonize any and every island
only build naval troops as needed
Trade with american neighbors until you are able to circumnavigate
Once I made contact with the rest of the world, I was in second place in tech (behind my American neighbor). Closing the rationalism tree closed out the space race.