Saw the arrival of the game at 2am local time and of course did the stupid thing, started the traditional Egypt game immediately, former Emperor level (why the renaming...) and played it more or less until my body gave emergency signals.
It's surprisingly overwhelming at first even if you think you're prepared by the Previews and Twitch guys (Did Firaxis ask
any women to preview, btw? - anyway...).
Didn't really get into any kind of strategy, just reacting to what was happening. (Partly because the Independents kept me on my toes and razed my first attempt of a second town mercilessly.)
Still, there seem to be a lot of strategic options early on (ways to spend money, influence etc.), so I'm confident it will get even more interesting when the learning curve eventually levels off.
I got a nice egypty start between two broad rivers (Standard Fractal map, lots of character in the map and not a blocky landmass at all), but there was a comical lack of river-adjacent desert tiles to place my Pyramids on (it is a
very specific requirement). There was plenty of desert, but always a stupid lake tile or something in the wrong place inbetween. So this first game is already ruined.

What also got me off on a slower foot - I forgot you can't just cross a navigable river with your town expansion at first. So you end up with cramped space for your capital if you immediately settle on the Nile delta.
Overall some signs that the city puzzle might get even more headachy in this iteration.
Still - I was immersed and had fun in this first half-age.
The interactions with NPCs are fine gameplay-wise, but could use a bit more emotional grounding. The grunts and sighs feel... awkward. And there's a lack of visual distinction for the independent units - if you meet five IPs early, it's hard to care who's in front of you in particular. At least the hostile ones got a red outline, thank Sid. Those got stressful in a hurry and razed my careless attempt of a second town mercilessly. Also: the sniping boats were an early menace at the coasts. (a positive in my book, just hope the major AIs can deal with it)
The UX in general absolutely needs work, just clunky spots everywhere between some clever bits, but I'm sure they'll deliver it and narrow it down to a couple of annoyances, like they will always remain in every Civ til the end of time. Seeing the game evolve is a big part of the fun anyway.