Vista will tell you about the "Known compatibility issues" with Vanilla until it is patched to 1.74. You also have to run the game as Administrator by right clicking and choosing "Run as Admin..."I have an HP Pavilion with Vista, when I bring up vanilla CIV IV I get a windows error warning saying that this program has known compatibility issues. This is frustrating since all of my earlier versions of CIV and their expansion pack work fine, grrrrr. Is this a driver issue?
See the sticky of "Lemon's Civ/Vista Guide" for details on how to do this, as there are some pictures there of the menus you will see, and how to do it so it always starts that way.
Good luck.
