You can do alot of things if the map is generous or forgiving. I'm assuming Mylene and Iranon are talking about close or tough games. There is little use for more overall beakers from a settled GS, if that means you don't get the advantage you need to break out of a tricky situation.
I dont see why anyone would choose to play a poor start to the highest difficulty levels.
There is little use for bulbing if the AI has already researched the bulb tech too. Bulbing doesnt always give you an advantage, the only techs that are worth it are Philosophy if you can get it before anyone else, and Education due to how expensive it is, and both of these get you to Liberalism faster.
PHI, SPI and IND give you far less advantage on the highest difficulties than CRE, EXP and ORG do. FIN is ok, but when I used to play Hannibal exclusively on Immortal difficulties my Cities used to fall so far behind in development, and when I moved on to playing Sury or Mehmed and learned to manage a specialist economy, my cities were being built up and developed unbelievably quicker. Half production buildings for all your cities is unbeatable, and the more the better. Colosseums and Theatres are actually insanely good for growing your cities for just 40 and 25
